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By week 12, clinical trial participants lost an average of 8.7% of their body weight across all doses, with the 12mg group reaching close to 10%

When you lose fluids through diarrhea, you also lose essential electrolytes including sodium, potassium, chloride, and magnesium

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As a result, the discontinuation rates attributed directly to side effects were relatively low and, importantly, were not substantially higher than those recorded in the placebo groups

This is not due to a direct chemical interaction, but rather an additive effect on the digestive system

Given the unknowns about its effects in pregnant humans, patients taking semaglutide who want to conceive should stop at least two months before a pregnancy, the FDA spokesperson said