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Neither option addresses the root cause of hormonal imbalance

The FDA-approved prescribing information for semaglutide and tirzepatide does not list HRT as a contraindication, and no direct pharmacological interaction between these medication classes has been established in clinical trials

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GDP, widespread uptake of drugs costing $1,000 per patient per month will have a profound impact on national healthcare spending during a time where policymakers are focused on reining in costs
They are usually taken on different schedules

doi: 10.3390/ijms21051725 216 XiongHZhengCWangJSongJZhaoGShenHet al