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Baseball Hall of Famer Tony Gwynn's death from oral cancer two years ago spurred a renewed look at the risks of smokeless tobacco, which has been connected to a higher risk of several types of cancer and other ailments

The cause is not completely understood but involves a T cell-mediated immune response triggered by a variety of factors which may include nutritional deficiencies, local trauma, stress, hormonal influences, allergies, genetic predisposition, certain foods, dehydration, some food additives, or some hygienic chemical additives like SDS (common in toothpaste)

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UChicago Medicine

Itching, burning, irritation, painful intimacy, and shifts in discharge can linger for months or even years

Add in individual tolerance and you may experience sooner or later satisfaction than the math suggests