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For patients requiring triple therapy, GLP-1 receptor agonists can be combined with metformin and a sodiumglucose cotransporter 2 inhibitor in patients with persistent hyperglycemia

Another GLP-1 analogue, exenatide, has also shown promising results against neurodegenerative diseases in a pre-clinical study (53)

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Moreover, the different agonists act differently on the second messenger systems

Extended Data Figure 3 The GLP-1R StaR B-factors and electron density

There are a myriad of medical benefits derived from these medications, including improvements in chronic medical conditions such as hypertension, hyperlipidemia, and sleep apnea, says Lauren Turchin-Orent, MD