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It is noteworthy that the combined GIPR antagonist and GLP-1R agonist AMG 133 demonstrated a body-weight loss of 14.5% at the highest dose (420 mg every 4 weeks) after 12 weeks in a Phase I trial, and this compound will now enter Phase II trials [48]

Discussion In the current systematic review and meta-analysis, 10 RCTs were analyzed to evaluate the effectiveness and safety of combination therapy with SGLT-2i and GLP-1RA compared to monotherapy of each individually on the incidence of MACE and hospitalization for heart failure

Average weight loss: 510% over 12 weeks

Cardiovascular outcomes: Does the triple mechanism provide CV benefits beyond weight loss

Cagrilintide targets another hormone, amylin

[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Malik VS, Willet WC, Hu FB