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doi: 10.1021/acs.est.5b02135 231 LehmlerHJLiuBGadogbeMBaoW

Tufted astrocytes, characterised by accumulation of tau in proximal astrocytic processes, represent the histopathological hallmark of progressive supranuclear palsy, a rare neurodegenerative disorder with progressive impairment of balance, walking, eye movement, muscular rigidity, dysarthria, and dysphagia

This solution was further diluted with corn oil to prepare stock solutions containing 50 and 450 g/mL [ 13 C 4 ]-furan

We also found that the tetranor-PGDM and tetranor-PGEM concentrations were increased in parallel with disease severity, with higher values observed in patients without ambulatory function, such as those with severe and typical FCMD, compared to those with the ambulatory mild FCMD phenotype

Furthermore, there are also components with species-specific effects when it comes to modulation of the channel

This difference was achieved without any change in food intake, suggesting the weight loss came from metabolic changes rather than appetite suppression