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Description
Semaglutide is frequently used off-label for PCOS due to its powerful effects on insulin resistance and ovulation
Evidence comes from large-scale studies such as the SCALE and LEAD trials for liraglutide, the STEP 18 program for semaglutide, the SURMOUNT 14 trials for tirzepatide, AWARD-11 for dulaglutide, and DURATION-1 for exenatide (Table 3)
Some employer-sponsored plans still include it, but they are becoming rarer
The increased risk of bleeding due to drug-drug interactions in patients administered direct oral anticoagulants
The dietary component of tirzepatide treatment parallels semaglutide
The platform has attracted significant patient interest as GLP-1 medications have demonstrated weight-loss efficacy of 1522% body weight reduction in clinical trials over 68 weeks
