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this shallow depth prevents intramuscular injection, which would alter how the body absorbs the medication

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As peptide bonds break down, byproducts can form that trigger immune responses or localized injection-site reactions

(287) demonstrated that inflammation of the muscularis externa of the small intestine caused by manipulation following laparotomy caused the upregulation of C-C chemokine family ligand (CCL)2 (monocyte chemoattractant protein-1) and colony-stimulating factor (CSF)-1 by enteric glia that promote the recruitment of monocytes to the muscularis and their differentiation into pro-resolving macrophages leading to tissue recovery

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