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Reductions in GABA levels found in patients with ALS in motor cortex compared to healthy controls (Foerster et al., 2012, 2013) may contribute to cortical hyperexcitability

McGarry, S

Antidepressants that act at serotonin and noradrenaline reuptake are clinically relevant in CIPN treatment [19]
Although discovered over 150 years ago, the action of the kynurenine pathways intermediate metabolites, known as kynurenines, has until recently been relatively little studied (Schwarcz et al., 2012)
& Levitan, I
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