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These observations suggest that mitochondrial stress responses can propagate systemically and may become amplified under conditions of GLP-1RAinduced chronic energy flux constriction, where nutrient inflow is reduced while oxidative demand persists

However, GLP-1RAs also modestly reduce systolic blood pressure (SBP) by 24 mmHg (66)

Do Nascimento et al conducted a systematic review and meta-analysis showing that GLP-1RA use was associated with an increased risk of pre-procedural gastrointestinal symptoms (odds ratio 7.66

In addition, recent studies suggest that GLP-1s may be linked with a rare yet serious condition called nonarteritic anterior ischemic optic neuropathy (NAION)

Molecular Metabolism, 30, 72130

doi: 10.1055/s-0031-1271777 49 Ben NasrMUsuelliVDellepianeSSeelamAJFiorentinoTVDAddioFet al