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While cortisone is highly effective at quickly reducing inflammation and pain, it can cause issues with long-term use, such as tissue atrophy, weakened tendons, and blood sugar elevation

To begin with, PD patients are more prone to developing Vit B12 deficiency which may be linked to several factors such as typical low-protein diet in LDopa treated PD, delayed gastric emptying due to autonomic dysfunction, bacterial overgrowth along with helicobacter pylori (HP) infection aggravated by the occurrence of constipation (Fasano et al

They range from mild to debilitating and life-threatening

Journal of Clinical Endocrinology & Metabolism, 91(3), 799805

In compounding, hydroxocobalamin may be used to create specific formulations for patients with unique needs or preferences, such as those who require alternative delivery methods or have allergies or sensitivities to other forms of vitamin B12