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They exposed mice to smoke from twenty cigarettes a day, six days a week, for a few weeks, using a machine to pump the smoke into their environment

For cloth seats & carpets: Use a car upholstery shampoo or extractor Scrub gently but thoroughly Remove as much moisture as possible after cleaning For leather seats: Clean with a leather-safe cleaner Follow with a leather conditioner (dry leather traps odors) Pro tip: If smoke smell is strong, one pass is usually not enoughrepeat cleaning once surfaces fully dry

So, next time you watch one of these classic films, pay attention to the way a simple cigar can transform a character and elevate a scene to iconic status.

Depression and self-medication with nicotine: the modifying influence of the dopamine D4 receptor gene

To view a copy of this licence, visit About this article Cite this article Lee, P.N., Coombs, K.J

It was a real nightmare