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Curiously, like the livers of Gsr-null mice reported a decade earlier by Rogers and colleagues [110], TrxR1/Gsr-null livers exhibit no detectable GSSG-reductase activity, yet they maintain normal or higher levels of total GSH, of which nearly all is in the reduced form [107, 108]

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however, Compounds 1.62 and 1.64 , both with changes in D-cysteine stereochemistry, showed a loss of activity with GPx or GR

There was a statistically significant decline in cohort 3, which had shown the greatest improvement during treatment, with no significant change for cohorts 1 and 2 (Supplemental Table 2)

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