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Topiramate has similar benefits for weight reduction in psychiatric patients, but cognitive impairment limits its usage (McIntyre RS et al, Am J Psychiatry 2024;181(1):2638)

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Thus, determining a clearer understanding of the mechanism of action would allow the initiation of large-scale clinical trials needed to determine the potency, safety, and efficacy of these molecules on neurodegenerative disorders

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However, some providers use gradual dose exposure to help patients adapt to GLP-1 medications while monitoring tolerance