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For approved SGLT2 inhibitors there is on average some 1.52 kg weight loss (placebo-adjusted), for GLP1-RAs 24 kg, and for the combination 35 kg [17,18,19,20,21,22,23]

The PlexusDx Precision Peptide Genetic Test ($99 add-on after your first month) analyzes 14 metabolic pathways and 49 peptides, including genetic variants in GLP1R (rs6923761), GIPR (rs1800437), and MC4R (rs17782313) that influence how your body responds to GLP-1 therapy

Protocol for those on mid-dose tirzepatide (7.5 to 10mg) You are the most common transition candidate

Moreover, patients using exenatide BID together with titrated insulin glargine (with or without metformin or pioglitazone or both) observed similar rates of hypoglycaemia but significantly greater reductions in HbA1c compared to patients using placebo and insulin (Table 1) [41]

[20] Patients should be aware of red flags requiring medical attention, including severe persistent abdominal pain (possible pancreatitis), severe or persistent vomiting leading to dehydration, symptoms of gallbladder disease, vision changes, or allergic reactions