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Acta Pharmacol Sin 29:713719

Association of Semaglutide with Reduced Incidence and Relapse of Cannabis Use Disorder in Real-World Populations: A Retrospective Cohort Study

The presence of GLP-1R in MCs has been confirmed by multiple research groups, including our own 5,15,16 and ex vivo data have shown that MCs increase their action potential firing frequency after the addition of both GLP-1 and the GLP-1R agonist exendin-4 17

The Origins and Mechanism of GLP-1 Agonists GLP-1, or glucagon-like peptide-1, is a naturally occurring compound in our bodies that plays a crucial role in regulating blood sugar levels and appetite

Proc Natl Acad Sci USA 80:54855489

GLP-1RA therapy inhibits glucagon secretion, at least transiently delays gastric emptying, and reduces appetite and food intake [60,61]