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MINocyclinE to Reduce inflammation and blood-brain barrier leakage in small Vessel diseAse (MINERVA): A phase II, randomized, double-blind, placebo-controlled experimental medicine trial

Despite evidence of myocardial inflammation and oxidative stress in TTS, systemic biochemical validation remains limited

The double increase in Asc in ischemic tissue compared to healthy tissue indicates increased ROS formation under ischemic conditions and confirms the role of oxidative stress in ischemia

Higher concentrations allow smaller injection volumes but may increase injection site discomfort

Is it because of individual variability

On that account, innate beneficial effect, Roberts stomach cytoprotection/adaptive cytoprotection/organoprotection 14 - 19 tolerates the lack of the full understanding of the involved mechanisms, specific cellular changes seldom identified, the surface epithelial cells not protected, electrophysiologic parameters (potential difference) instead macroscopic/microscopic assessments