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Despite the limitations of peptides, such as poor metabolic stability and low bioavailability, modified peptides show promise in addressing these challenges

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19 Curcumin is hydrophobic and has poor bioavailability because of its rapid metabolism in the liver and intestinal wall and because it is quickly cleared from the plasma, further limiting its therapeutic utility

In tendon fibroblast studies, BPC-157 was associated with increased expression of growth hormone receptor and collagen-related genes

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