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Overproduction of mucus : Smoking increases mucus production, which clogs the airways and results in coughing and breathing problems

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4-hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease

Second, although efforts were made to account for potential pleiotropy, its presence could not be excluded definitively because it could introduce distortion in causal effect estimation

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Smoking impairs healing through vasoconstriction, reducing the blood supply to healing tissue, and through the negative pressure of inhaling, which can physically dislodge the protective blood clot