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Bent S, Lawton B, Warren T, et al

doi: 10.1155/2014/416892

[37] In the early morning, the appearance of light causes PER and TIM proteins to break down in a network of transcriptional activation and repression

In particular, systemic administration often results in rapid clearance, low bioavailability, and poor targeting specificity

Children under 2 years should not receive diphenhydramine without specialist oversight because of reported paradoxical excitation and respiratory events

Study approval All procedures were conducted in accordance with the ethical guidelines and approved by the Animal Ethics and Welfare Committee of Sun Yat-sen Memorial Hospital, Sun Yat-sen University (Approval No.: AP20220236)