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Both medications benefit from microdosing protocols, but patients intolerant to semaglutide even with slow titration may tolerate tirzepatide better

Data from participants without events of interest were censored at the end of their in-trial period

These improvements can greatly enhance the quality of life and further decrease health-related expenditures

Improve energy levels and support cellular function
SUSTAIN Trial: Cardiovascular Outcomes in Patients with Type 2 Diabetes The SUSTAIN-6 trial studied semaglutide in people with type 2 diabetes who were at high risk for heart disease

A Phase 1 healthy-volunteer study later confirmed rapid absorption, a 67-day half-life, and a favorable tolerability profile [Nature Communications]