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Patients with insulin resistance, metabolic syndrome, or a family history of obesity may respond especially well to GLP-1 medications due to their action on glucose metabolism and insulin secretion

Arguably, the most clinically relevant basis for the potential of GLP-1 RAs in HF could be their effect on multiple cardiometabolic parameters that play intertwined roles across the HF-related diseases such as diabetes and obesity, which often co-exist