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Unlike insurance claims data, which tend to reflect usage among diabetic or obese patients with treatment covered by insurance, Numerators data also capture households that use GLP-1 drugs off-label, including many who pay out of pocket and do not meet the clinical criteria for obesity, providing a broader view of adoption patterns

iScience 23 , 100961 (2020)

2017 Jan 12 [cited 2018 Dec 3];27(1):221

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How safety data affects the approval timeline The dysesthesia signal will not necessarily prevent approval, but it will shape the labeling and potentially the approved dose range