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221,222 Ischemic necrosis of myocardial tissue triggers biomechanical changes during cardiac contraction and relaxation, which activate myofibroblasts to produce excessive collagen

During hepatic regeneration, increased activity of urokinase plasminogen activator (uPA) triggers extracellular matrix (ECM) remodeling involving cascades of metalloproteinase activation which lead to the release of active HGF in the ambient environment of hepatocytes and in circulation and this is followed by a plethora of events to restore the architecture of the liver 41,42

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