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Jennifer Hauler, DO, MBA Dually board-certified family medicine and emergency medicine physician Chief operating officer, Houston Methodist Hospital Board member, American Osteopathic Association Disclosures: Hauler reports no relevant financial disclosures

The two approved for weight management are semaglutide (Wegovy) and tirzepatide (Zepbound)

Molecular and biochemical studies have shown that estrogens may also exert transcriptional effects via proteinprotein interactions with other transcription factors (Marino et al., 2006

Men are statistically less likely to seek weight loss treatment despite having similar obesity rates to women

If you notice your resting heart rate has increased by more than 10-15 beats per minute, or if you experience heart palpitations, lightheadedness, or chest discomfort, contact your provider immediately

This distinction underscores the importance of viewing GLP-1RAs as systemic immunometabolic modulators with secondary effects on thyroid autoimmunity, rather than as agents with direct thyroidal targets
