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With a growing number of patients using these medications for diabetes or to meet certain optimization goals before undergoing hip and knee reconstructive surgery, our aim was to establish evidence-based guidelines on when to discontinue these to enhance patient safety and surgical success. The study, Optimal Timing for Cessation of GLP-1 Agonist Before Elective Total Hip and Knee Arthroplasty, obtained data from the TriNetX Research Network, a multi-institutional national aggregated database, to identify patients who underwent TKA or THA from January 1, 2018 to January 1, 2023

GLP-1 receptor agonists are medications that increase the levels of this hormone in the body and restore its beneficial effects on blood sugars, sensations of fullness, and weight management

Semaglutide is one of the most powerful

Some patients pursue out-of-network reimbursement for FDA-approved branded medications, but the compounded tablet path is generally not covered

We actually see a 25% reduction in suicidal ideation, Al-Aly noted

No guaranteed results