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These results led us to speculate that GDF15 is downregulated in the process of GC-induced ferroptosis and that MT treatment might increase the expression of GDF15, which exerts the ability to neutralize ROS and alleviate ferroptosis

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While nitric oxide, hydrogen peroxide, hypochlorite, and superoxide are well characterized molecular components of the innate immune response, these molecules give rise to numerous secondary metabolites that may also contribute to host defense against infection

doi: 10.1038/leu.2015.247 65 O'SullivanD

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