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Pancreatitis (inflammation of the pancreas) is a serious but rare adverse effect that presents with severe, persistent abdominal pain radiating to the back, often accompanied by nausea and vomiting

(2025), in a network meta-analysis of 22 RCTs (2,258 participants) published in Metabolism, reported a mean difference of 0.86 kg lean mass for GLP-1 receptor agonists versus placebo, corresponding to roughly 25% of total weight loss

Abruptly discontinuing GLP-1 therapy can trigger a cascade of unwanted effects

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You may get hungrier than you did before or feel more fatigued

Although generally regarded as a desirable outcome by most patients, the facial soft tissues often fail to adapt proportionally to the sudden reduction in volume