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it can be considered as another limitation of our study

While drug expulsion from SLNs is caused by a reduction of amorphous regions in the lipid matrix due to a polymorphic transition from the less-ordered -form to the more-ordered -form, which reduces the space available for drug molecules, the drug is consequently expelled from the lipid core and may migrate to the particle surface or surrounding medium, leading to a gradual decrease in drug loading efficiency over time (Westesen et al., 1997

Ripristino dellEspressione Genica e Ringiovanimento Cellulare : Le analisi trascrittomiche rivelano che GHK-Cu pu riportare i profili di espressione genica delle cellule invecchiate a uno stato pi giovane, influenzando oltre 4.000 geni legati alla crescita cellulare, alla difesa antiossidante e alla riparazione

Its important to note that there could be a significant risk of blood clots in the arteries (arterial thromboembolic events) and potentially life-threatening situations after the occurrence of CRAO

E.Stenkiewicz-WiteskaJ.De MaeyerR

Asparagine depletion potentiates the cytotoxic effect of chemotherapy against brain tumors