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Investigate Potential Underlying Causes Your healthcare provider may recommend investigations to exclude secondary causes of treatment resistance: Thyroid function tests (TSH, free T4) to screen for hypothyroidism HbA1c and fasting glucose to assess insulin resistance or diabetes Lipid profile as part of comprehensive metabolic assessment Sleep study referral if obstructive sleep apnoea is suspected NICE guidance (CG189) supports investigating these factors when weight management interventions prove ineffective

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[Abstract]2025 Mar 10:S2090-1232(25)00174-2

24 Cosmetics On December 29, 2022, the Modernization of Cosmetics Regulation Act (MoCRA) was signed into law expanding FDAs regulatory authority over cosmetic products