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Hogan AE, Tobin AM, Ahern T, et al

Discussion Principal findings This network meta-analysis comprehensively evaluated and compared the efficacy and safety of 15 GLP-1RAs in adults with type 2 diabetes, including the latest novel drugs (orforglipron, retatrutide, and CagriSema, etc)

adults with the same age and gender distribution who consider themselves overweight but are not using a GLP-1 medication)

Bottom Line on Cost: Oral semaglutide costs about the same as brand-name injectables but delivers only 20-30% of the weight loss results

doi: 10.2337/DB18-0317 53 ZhengZZongYMaYTianYPangYZhangCet al