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Overall, these multilayered epigenetic and epitranscriptomic mechanisms collectively enable DTPs to rapidly adapt to therapeutic challenges

Additionally, increased expression of the NLRP3 inflammasome, Caspase-1, GSDMD, and the pro-inflammatory cytokines IL-1 and IL-18 was observed

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Within the TCA cycle, citrate provides the carbon source for DNL, -KG is interconvertible with glutamate, and oxaloacetate serves as a substrate for aspartate synthesis

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