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Treatment of DIO mice with PYYMK-801 and GIPMK-801 did not affect body weight or food intake beyond that of the parent peptide analogues (Extended Data Fig
When used as medication, GLP-1 RAs increase insulin production when blood sugar is high, reduce the amount of glucagon (a hormone that raises blood sugar), slow digestion, and increase feelings of fullness

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Glucose, as an osmotically active molecule, may reduce osmotic pressure by bringing water from the interstitium to the vessels, triggering retinal edema
