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Aetiological factors for penile SCC are similar to those for PIN, including increasing age, presence of a foreskin (neonatal circumcision reduces the risk), phimosis, chronic inflammatory genital disease (mostly penile lichen sclerosus), smoking, treatment with photochemotherapy (psoralen and ultraviolet A [PUVA] therapy), multiple sexual partners (with earlier onset of sexual activity) and immunosuppression

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In ihrer natrlichen (R)-Form spielt sie eine wichtige Rolle als Coenzym in den Mitochondrien und ist daher wesentlich am Energiestoffwechsel der Zellen beteiligt

Taken together, these data demonstrated that iron supplementation rescues all phenotypes associated with the mutant diets