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The majority of the published literature examines each compound independently, and the synergy hypothesis, while mechanistically well-supported, has not yet been the subject of large-scale controlled studies

Indian Pediatr

Theres no research on the long-term effects of chanca piedra, so it may be wise to limit the time you take the supplement to 12 weeks or less a duration that has been studied in humans ( In the studies that have been done on chanca piedra, there doesnt appear to be any risks to stopping the supplement suddenly

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The gene encoding GS was cloned in 1995 (Huang et al., 1995) but its transcriptional regulation has only been characterized recently after cloning of the rat and human GS promoters (Yang et al., 2002