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Distinct biomarkers such as IGF-1 (OR 1.06), fasting glicentin (AUC 0.81), HbA1c (AUC 0.76), and absolute weight reduction (AUC 0.72), greater fluctuations in glucose (OR 1.98) are valuable in promptly detecting MBSH

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Weekly GLP-1 injections with ongoing monitoring.

Regardless of drugs, lifestyle matters: physical activity, healthy diet, sleep, social connection, cognitive engagementall are evidence-based pillars of brain health

Moreover, the efficacy of these drugs in MC4R KO mice aligns with clinical studies, indicating that MC4R KO mice serve as a reliable animal model for obesity research.