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While bariatric surgery has positive long-term benefits in many patients, uptake of the procedure is historically low due to several barriers including provider and patient knowledge and attitudes, access to care, and cost
Selection bias may have affected the generalizability of our findings
For orforglipron, participants initiated on higher doses and those on rapid titration schemes appeared to have higher discontinuation rates, providing insights into the optimisation process for the phase 3 trials

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In just 6 years after launch, more than 2% of Americans are taking this drug