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Resveratrol is capable of elevating the methylation status of Nfe2l2 gene while lowering that of Keap1, resulting in decreased Nrf2 expression and activity [266]

Therefore, for computational models to provide true in silico laboratories and complete understanding of the role of GSH in this complicated system it will be necessary to simulate molecular single-cell effects in the context of a multicellular system

Perry ID, Nguyen T, Sherina V, Love TMT, Miller RK, Krishnan L, Murphy SP Placenta

J Virol , 2004

In a study with senescence-accelerated mice and normal aging controls, treatment with SF for about a year significantly improved long-term memory and increased hippocampal mRNA and protein levels of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC1) and mitochondrial transcription factor A (TFAM), both of which are master regulators of mitochondrial biogenesis