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Your Optum Rx partner can help you craft design changes and the utilization management structure necessary to help ensure appropriate use of GLP-1 drugs

Borg CM, le Roux CW, Ghatei MA, Bloom SR, Patel AG, Aylwin SJ

Clinical Management of Intermittent Fasting in Patients with Diabetes Mellitus (Grajower & Horne) Nutrients (MDPI) 2019 Supports the hypoglycemia-risk claims: insulin and sulfonylureas are the medications most likely to cause dangerous lows during fasting, doses often need reduction/adjustment, and prescriber involvement plus glucose monitoring are required before changing meal timing

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Switching to a different GLP-1 medication, reducing the dose, or considering alternative drug classes may be appropriate if symptoms remain intolerable

Hypomagnesemia and Hypocalcemia (severely reduced food intake) "People taking GLP-1 RAs may experience a decrease in magnesium and calcium intake as a result of reduced overall dietary intake," Dr