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In regard to the effects of GLP-1 in weight loss, extensive evidence demonstrates that GLP-1R agonism reduces food intake, thus promoting weight loss

But they also pose challenges: muscle loss, under fuelling and injury risk are real concerns

Such studies should incorporate systematic assessment of total, bioavailable, and free testosterone levels, as well as estradiol, during pharmacologically induced weight loss in order to clarify whether normalization of the endocrine milieu mitigates lean mass decline

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This structural advantage gives tesamorelin a longer duration of action and a more potent GH response