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Can HRT do more harm than good

Unlike injectable formulations that typically require cold-chain storage, oral GLP-1RAs bypass refrigeration constraints, thereby reducing manufacturing and distribution costs and improving accessibility in resource-limited settings [73]

doi: 10.4103/aca.aca_214_20

Injectable GLP-1 medications can be given at any time, but oral semaglutide (Rybelsus) also requires fasting administration, so consider bedtime levothyroxine dosing with careful TSH monitoring
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When caloric intake drops significantly, the resulting energy deficit can manifest as fatigue, weakness, or reduced exercise tolerance