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22 , 29, 30, 31 On the basis of this rationale, several clinical trials have been conducted and the results showed that hypomethylating agents (e.g., guadecitabine, decitabine, and azacitidine) can partially restore sensitivity to platinum agents in patients with PROC.32, 33, 34, 35, 36 Besides, transmembrane protein 88 (TMEM88), gelsolin and FANCF promoter hypomethylation are associated with platinum resistance in OC.37, 38, 39 Nuclear CD55 is reported to bind to and suppress ZMYND8 expression, thus derepressing PRC2 to increase H3K27me3, leading to platinum resistance in OC

JAMA Intern Med 2015;175:1518 10.1001/jamainternmed.2015.3528 [DOI] [PubMed] [Google Scholar] 3

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