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Similar regulatory mechanisms may drive PA EC calcification in different types of PH, and PAH patients with BMPR2 mutations or BMP signaling pathway impairments (104) would be expected to be specifically vulnerable in this scenario given the association of impaired BMPR2 signaling with EndoMT (211)

In vitro assays with 3,4- cis -leucocyanidin (6) Standard reaction conditions for in vitro one-step and two-step biotransformations of 3,4- cis -leucocyanidin ( 6 ) were 100 mM MOPSO, pH 6.2, 20 mM sodium ascorbate, 1 mM -ketoglutaric acid, 0.4 mM ammonium iron(II) sulfate, 200 M 3,4- cis -leucocyanidin ( 6 ) and 20 M GSH

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