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In addition, -syn and p--syn levels increased in the insoluble fraction of RIPA following hypoxic treatment for 7 days, suggesting that hypoxia promoted the phosphorylation of -syn and long-term hypoxia promoted -syn to form abnormal aggregates in the insoluble fraction (Fig

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doi: 10.1161/CIRCRESAHA.109.198366 38 Gonzlez EsquivelDRamrez-OrtegaDPinedaBCastroNRosCPrez de la CruzV

8 Mitochondrial disorders can cause organ failure, seizures, stroke-like episodes and premature death

Further research is still needed to confirm these findings

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