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Tumor-repopulating cells induce PD-1 expression in CD8(+) T cells by transferring kynurenine and AhR activation

Slower escalation with better tolerance produces better long-term adherence and results than aggressive dosing that causes misery

This review provides a systematic synthesis of the molecular and immunometabolic mechanisms underlying Treg exhaustion in uveitis, emphasizing both universal pathways and subtype-specific mechanisms

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For this reason, many scientists have redirected their focus towards therapies based on the opposite mechanism