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showed that the direction of flow was an important stimulus for regulating the EC gene expression profile, as activation of the eNOS pathway was maximal when ECs were parallel to the flow, whereas NFkB signaling was active when the ECs were perpendicular to the direction of the flow 33

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Caffeine toxicity : Rectal absorption of caffeine can cause tachycardia, arrhythmias, agitation, and tremor

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