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The Lancet 371:651659
On the other hand, internalization by deltorphin analogues is associated with partial recycling and resensitization of DOR signalling [88], both of which may contribute to a faster recovery of analgesic efficacy upon repeated administration of this type of ligands [86]
Wright ML, et al
Key takeaway: Beyond fat burning, AOD-9604 may have broader metabolic effects
The immune response to this damage, characterized by M1 macrophage polarization, neutrophilic inflammation, and Th17 activation, further exacerbates lipid peroxidation and ferroptosis, creating a vicious cycle that drives disease progression
RF drafted the manuscript
