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However, hypothalamic damage or disrupted hypothalamic development in humans results in hyperphagia and reduced energy expenditure, implying that the hypothalamus is likely to play a similar role in the physiology of human satiety and energy regulation

The discovery of leptin almost 30 years ago as an adipocyte-derived hormone has attracted attention toward developing antiobesity therapies because of leptins potent effects in reducing food intake and enhancing energy expenditure (59)

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As positive and negative controls, 0.008 ng/L of recombinant mouse ACE2 (3437-ZN-010, R&D Systems) and lysis buffer alone were used, respectively

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Corey Howard