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Toxicology Reports

10.3390/biom9030100 17

Vitamin B12 replacement therapy: how much is enough

On the other hand, the concentrations of total acylcarnitines and total carnitines of the patient group were 21.95 7.66 mol/L and 67.33 18.27 mol/L, respectively, which were higher than the control group (total acylcarnitine = 20.96 5.61 mol/L

Adjusting the Normal Dose of B12 Injection for Severe Cases For severe vitamin B12 deficiency, higher doses might be needed to quickly fill up body stores

Glutathione peroxidase 4 (GPX4), glutathione (GSH), and cystine/glutamate antiporter system (System Xc-) including solute carrier family 7 member 11 (SLC7A11), play an important role in cellular antioxidant system, which can rescue cells from ferroptosis [21, 22]