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Angiotensin II causes efferent arteriole constriction to maintain glomerular filtration despite low systemic pressure, while aldosterone promotes distal sodium reabsorption

That receptor spread is the reason people sometimes describe retatrutide as a "triple agonist" or, informally, a next-generation GLP-class compound

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, 6 , 61, Ji, Z., He, L., Regev, A., and Struhl, K

J Biol Chem (2013) 288(14):9790800

World J Microbiol Biotechnol 39:53
